Bio Medical Engineering Course

Lesson 1 • Human Anatomy and Physiology Review

Covers organ systems, cellular structure, and homeostatic mechanisms relevant to device design. Bridges life-science prerequisites with engineering problem-solving.

Lesson 2 • Scope and History of the Field

Traces the evolution of biomedical engineering from early prosthetics to modern implants. Provides historical context that motivates the technical depth covered throughout the course.

Lesson 3 • Regulatory and Ethical Framework

Introduces device classification, safety standards, and ethical obligations in biomedical practice. Grounds students in compliance thinking before they encounter design tasks.

Lesson 1 • Mechanical Properties of Biomaterials

Analyzes stress-strain behavior, fatigue, and fracture mechanics in biological environments. Provides quantitative tools for predicting device longevity under cyclic loading.

Lesson 2 • Material Selection and Testing Standards

Applies structured selection matrices and standardized biocompatibility testing protocols. Connects material science to regulatory submission requirements.

Lesson 3 • Classes of Biomaterials

Surveys metals, polymers, ceramics, and composites used in medical applications. Connects material class to mechanical and chemical performance requirements.

Lesson 4 • Biocompatibility and Host Response

Explains protein adsorption, inflammation cascades, and foreign-body reactions triggered by implants. Links biological response to surface chemistry and material choice.

Lesson 1 • Fluid Mechanics in Physiology

Applies Navier-Stokes equations and non-Newtonian flow models to blood and lymph circulation. Underpins cardiovascular device design and hemodynamic analysis.

Lesson 2 • Mechanobiology and Tissue Adaptation

Examines how mechanical stimuli regulate cell signaling, gene expression, and tissue remodeling. Connects biomechanics to tissue engineering and regenerative strategies.

Lesson 3 • Mechanics of Hard Tissues

Characterizes bone and cartilage as composite materials under compressive, tensile, and shear loads. Provides data needed for implant fixation and fracture fixation design.

Lesson 4 • Statics and Dynamics of the Human Body

Models the musculoskeletal system using free-body diagrams and Newton's laws. Establishes load calculations essential for orthopedic and rehabilitation device design.

Lesson 1 • Sensor Principles and Transduction

Covers resistive, capacitive, piezoelectric, and optical transduction mechanisms used in biomedical sensors. Establishes the physical basis for converting physiological variables to electrical signals.

Lesson 2 • Biopotential Electrodes and Amplifiers

Analyzes electrode-electrolyte interfaces and differential amplifier design for ECG, EEG, and EMG. Directly enables acquisition of clinically relevant electrical biosignals.

Lesson 3 • Data Acquisition and Digitization

Covers ADC selection, sampling theory, and real-time data streaming for physiological systems. Links analog front-end design to digital processing pipelines.

Lesson 4 • Wearable and Implantable Sensor Systems

Addresses miniaturization, power harvesting, and wireless telemetry for body-worn and implanted devices. Integrates sensor, circuit, and communication design into complete systems.

Lesson 1 • Biosignal Analysis in Time Domain

Applies statistical descriptors, peak detection, and template matching to ECG, EEG, and EMG signals. Builds foundational analysis skills before frequency-domain methods are introduced.

Lesson 2 • Frequency-Domain and Spectral Methods

Uses Fourier and wavelet transforms to characterize spectral content of physiological signals. Enables detection of rhythmic pathologies and frequency-specific features.

Lesson 3 • Feature Extraction and Classification

Extracts morphological and texture features from signals and images for automated diagnosis. Introduces supervised classifiers and performance evaluation metrics.

Lesson 4 • Image Enhancement and Segmentation

Applies spatial filtering, histogram equalization, and region-based segmentation to medical images. Prepares students for quantitative morphological analysis of anatomical structures.

Lesson 1 • Design Verification and Validation

Distinguishes verification from validation and plans test protocols for both activities. Ensures the device meets design inputs and satisfies intended use in simulated clinical conditions.

Lesson 2 • Concept Generation and Selection

Applies brainstorming, morphological charts, and Pugh matrices to generate and select device concepts. Produces a justified concept choice ready for detailed design.

Lesson 3 • User Needs and Design Requirements

Translates clinical user needs into measurable design inputs using structured elicitation methods. Establishes the requirements baseline that drives all subsequent design decisions.

Lesson 4 • Quality Management in Device Development

Implements design history files, change control, and CAPA processes within a quality system. Prepares students to operate within regulated development environments.

Lesson 1 • Clinical Workflow Integration

Analyzes clinical pathways and care protocols to identify optimal device integration points. Ensures device design aligns with real-world clinical practice and staff workflows.

Lesson 2 • Interoperability and Data Standards

Implements messaging protocols and terminology standards for seamless device-to-system communication. Enables data sharing across devices, EHRs, and analytics platforms.

Lesson 3 • Human Factors and Usability Engineering

Applies use-error analysis, task analysis, and formative testing to reduce device-related adverse events. Directly supports regulatory usability submissions and safe clinical deployment.

Lesson 4 • Post-Market Surveillance and Vigilance

Establishes complaint handling, adverse event reporting, and field safety corrective action processes. Closes the development loop by feeding real-world performance data back into design.

Lesson 1 • Hydrogels and Extracellular Matrix Analogs

Formulates natural and synthetic hydrogels that mimic extracellular matrix mechanics and biochemistry. Supports encapsulation of cells and controlled delivery of growth factors.

Lesson 2 • Construct Characterization and Translation

Evaluates engineered tissues using histology, mechanical testing, and in vivo implantation models. Addresses regulatory and scale-up challenges for clinical translation.

Lesson 3 • Scaffold Design and Fabrication

Designs porous scaffolds using electrospinning, freeze-drying, and bioprinting to match tissue architecture. Links scaffold geometry and chemistry to cell attachment and tissue ingrowth.

Lesson 4 • Cell Sources and Culture Techniques

Compares primary cells, stem cells, and induced pluripotent sources for tissue engineering applications. Establishes cell handling competencies required for scaffold seeding and construct fabrication.