Hematologist Course

Lesson 1 • Thrombopoiesis and Platelet Biology

Covers megakaryocyte development and platelet release mechanisms. Prepares students for hemostasis and thrombocytopenia content in subsequent chapters.

Lesson 2 • Blood Composition and Cellular Elements

Covers erythrocytes, leukocytes, platelets, and plasma constituents. Provides the anatomical and functional baseline for all subsequent hematologic study.

Lesson 3 • Erythropoiesis and Hemoglobin Synthesis

Details red cell maturation stages and hemoglobin assembly. Connects synthesis defects to anemia subtypes introduced in later chapters.

Lesson 4 • Leukopoiesis and Immune Cell Development

Traces granulocyte, monocyte, and lymphocyte development from progenitors. Establishes the cellular immune framework needed for leukemia and lymphoma chapters.

Lesson 1 • Molecular and Cytogenetic Testing

Introduces karyotyping, FISH, and PCR-based assays used in hematologic diagnosis. Connects genetic findings to prognosis and targeted therapy selection.

Lesson 2 • Complete Blood Count Analysis

Teaches systematic interpretation of CBC parameters including indices and differentials. Forms the primary diagnostic tool used throughout all clinical chapters.

Lesson 3 • Flow Cytometry in Hematology

Explains immunophenotyping principles and panel design for blood and marrow specimens. Enables accurate lineage assignment in leukemia and lymphoma workup.

Lesson 4 • Peripheral Blood Smear Examination

Develops skills in preparing, staining, and reading blood smears for morphologic abnormalities. Directly supports diagnosis of anemias, leukemias, and hemolytic disorders.

Lesson 1 • Iron Deficiency and Iron Metabolism Disorders

Covers iron absorption, storage, and deficiency states including anemia of chronic disease. Teaches laboratory differentiation and evidence-based iron replacement strategies.

Lesson 2 • Aplastic Anemia and Bone Marrow Failure

Addresses acquired and inherited marrow failure syndromes, including Fanconi anemia. Covers immunosuppressive therapy and transplant indications.

Lesson 3 • Anemia Classification Framework

Establishes morphologic and pathophysiologic classification systems for anemia. Provides the diagnostic scaffold applied in all subsequent anemia sections.

Lesson 4 • Megaloblastic and Nutritional Anemias

Examines B12 and folate deficiency mechanisms, neurologic sequelae, and treatment. Distinguishes nutritional from malabsorptive causes to guide targeted therapy.

Lesson 1 • Red Cell Membrane and Enzyme Disorders

Covers hereditary spherocytosis, elliptocytosis, and pyruvate kinase deficiency diagnosis. Links membrane protein defects to osmotic fragility and clinical severity.

Lesson 2 • Sickle Cell Disease Clinical Management

Covers acute complication management, preventive care, and disease-modifying agents. Integrates evidence-based protocols for hydroxyurea, transfusion, and transplant.

Lesson 3 • Sickle Cell Disease Pathophysiology

Explains HbS polymerization, vaso-occlusion, and end-organ damage mechanisms. Establishes the molecular basis for all sickle cell management strategies.

Lesson 4 • Unstable Hemoglobins and Methemoglobinemia

Addresses rare hemoglobin variants causing hemolysis or impaired oxygen delivery. Provides diagnostic and acute management frameworks for these uncommon presentations.

Lesson 1 • Thrombophilia and Venous Thromboembolism

Addresses inherited and acquired thrombophilic states and their clinical consequences. Teaches risk stratification, anticoagulation selection, and duration of therapy.

Lesson 2 • Coagulation Laboratory Testing

Teaches interpretation of PT, aPTT, thrombin time, and mixing studies. Connects test patterns to specific factor deficiencies and inhibitor states.

Lesson 3 • Platelet Disorders and Thrombocytopenia

Differentiates immune, consumptive, and production-failure thrombocytopenias. Covers ITP, TTP, HIT, and DIC diagnosis and management.

Lesson 4 • Inherited Bleeding Disorders

Covers hemophilia A and B, von Willebrand disease, and rare factor deficiencies. Teaches prophylaxis, on-demand therapy, and inhibitor management strategies.

Lesson 1 • Chronic Myeloid Leukemia

Explains BCR-ABL1 biology, disease phases, and tyrosine kinase inhibitor therapy. Teaches response monitoring, resistance mechanisms, and treatment-free remission criteria.

Lesson 2 • Chronic Lymphocytic Leukemia

Covers CLL staging, prognostic markers, and indications for initiating therapy. Teaches BTK inhibitor, BCL-2 inhibitor, and chemoimmunotherapy regimens.

Lesson 3 • Acute Lymphoblastic Leukemia

Addresses B-cell and T-cell ALL classification, risk stratification, and treatment protocols. Covers CNS prophylaxis, MRD monitoring, and CAR-T cell therapy indications.

Lesson 4 • Acute Myeloid Leukemia Treatment

Teaches induction, consolidation, and targeted therapy regimens for AML by risk group. Covers transplant indications and management of treatment-related toxicities.

Lesson 1 • Aggressive Non-Hodgkin Lymphomas

Addresses DLBCL, Burkitt lymphoma, and mantle cell lymphoma diagnosis and treatment. Covers cell-of-origin classification and its impact on therapeutic selection.

Lesson 2 • Indolent Non-Hodgkin Lymphomas

Covers follicular lymphoma, marginal zone lymphoma, and small lymphocytic lymphoma. Teaches watch-and-wait criteria, anti-CD20 therapy, and transformation risk.

Lesson 3 • Multiple Myeloma Diagnosis and Staging

Explains CRAB criteria, IMWG diagnostic standards, and R-ISS staging for myeloma. Connects cytogenetic risk to treatment intensity decisions.

Lesson 4 • Hodgkin Lymphoma Diagnosis and Treatment

Covers Reed-Sternberg cell biology, Ann Arbor staging, and risk-adapted therapy. Teaches PET-adapted treatment strategies and late-effect monitoring.

Lesson 1 • Polycythemia Vera and Essential Thrombocythemia

Covers JAK2 mutation biology, diagnostic criteria, and thrombosis risk management. Teaches cytoreductive therapy selection and phlebotomy protocols.

Lesson 2 • Myelodysplastic Syndromes Classification

Explains WHO MDS subtypes, somatic mutation landscape, and IPSS-R risk scoring. Establishes the diagnostic framework for treatment selection in the next section.

Lesson 3 • Systemic Mastocytosis and Rare Myeloid Disorders

Addresses KIT D816V mutation, WHO mastocytosis classification, and midostaurin therapy. Covers eosinophilic disorders and overlap myeloid neoplasm syndromes.

Lesson 4 • Myelodysplastic Syndrome Treatment

Covers supportive care, hypomethylating agents, lenalidomide, and transplant for MDS. Teaches response assessment and progression monitoring strategies.