Reproductive Endocrinology Course

Lesson 1 • Hypothalamic-Pituitary Axis

Covers GnRH pulsatility, gonadotropin release, and axis regulation. Central to understanding how the brain orchestrates reproductive hormone secretion.

Lesson 2 • Hormone Transport and Metabolism

Describes binding proteins, bioavailability, and hepatic metabolism of sex steroids. Explains why total vs. free hormone levels differ clinically.

Lesson 3 • Gonadal Hormone Biosynthesis

Explains steroidogenesis pathways in ovaries and testes, including enzyme roles. Links biochemical production to physiological reproductive function.

Lesson 4 • Reproductive Hormone Measurement

Covers immunoassay principles, mass spectrometry, and reference ranges for reproductive hormones. Ensures accurate interpretation of laboratory data used throughout the course.

Lesson 1 • Endometrial Cycle and Implantation

Examines proliferative and secretory endometrial changes driven by estrogen and progesterone. Directly relevant to understanding implantation failure and endometrial receptivity.

Lesson 2 • Folliculogenesis and Oocyte Development

Traces follicle recruitment, selection, and dominance from primordial to preovulatory stages. Establishes the cellular basis for ovarian reserve and fertility potential.

Lesson 3 • Puberty and Menarche

Describes the hormonal cascade initiating female puberty, including adrenarche and thelarche. Establishes normal developmental benchmarks used in pediatric and adolescent endocrinology.

Lesson 4 • Ovarian Reserve Assessment

Covers antral follicle count, AMH, and day-3 FSH as reserve markers. Provides tools for predicting ovarian response in clinical and assisted reproduction settings.

Lesson 1 • Androgen Physiology and Action

Covers testosterone biosynthesis, DHT conversion, and androgen receptor signaling. Essential for understanding hypogonadism, androgen excess, and therapeutic interventions.

Lesson 2 • Testicular Structure and Function

Reviews seminiferous tubule anatomy, Sertoli cell roles, and blood-testis barrier function. Provides the anatomical basis for understanding spermatogenesis and androgen production.

Lesson 3 • Semen Analysis and Interpretation

Applies WHO reference criteria to evaluate sperm concentration, motility, and morphology. Bridges laboratory findings to clinical diagnosis of male factor infertility.

Lesson 4 • Male Puberty and Hypogonadism

Describes testosterone-driven pubertal development and classifies hypogonadism by origin. Prepares students to distinguish primary from secondary causes in clinical evaluation.

Lesson 1 • Polycystic Ovary Syndrome

Covers PCOS diagnostic criteria, hormonal profile, and metabolic comorbidities. Prepares students to manage the most common cause of anovulatory infertility.

Lesson 2 • Abnormal Uterine Bleeding

Applies the PALM-COEIN classification to structural and non-structural causes of abnormal bleeding. Guides hormonal and surgical management decisions based on etiology.

Lesson 3 • Luteal Phase Deficiency

Defines inadequate progesterone support and its role in implantation failure and early pregnancy loss. Connects luteal function assessment to clinical supplementation strategies.

Lesson 4 • Hypothalamic Amenorrhea

Examines GnRH suppression from energy deficit, stress, and exercise in functional amenorrhea. Links neuroendocrine disruption to bone health and fertility consequences.

Lesson 1 • Defining and Classifying Infertility

Establishes clinical definitions of infertility, subfertility, and fecundability. Frames the epidemiological context and guides appropriate timing of evaluation initiation.

Lesson 2 • Uterine and Tubal Factor Assessment

Evaluates structural uterine anomalies and tubal disease as barriers to conception. Connects imaging findings to prognosis and surgical or assisted reproduction planning.

Lesson 3 • Male Infertility Evaluation

Integrates semen analysis, hormonal profiling, and genetic testing for male factor diagnosis. Identifies treatable vs. untreatable causes to guide management decisions.

Lesson 4 • Female Infertility Evaluation

Covers ovarian reserve testing, tubal patency assessment, and uterine cavity evaluation. Provides a complete diagnostic framework for identifying female-factor causes.

Lesson 1 • Ovulation Induction for Anovulation

Applies WHO anovulation classification to guide first- and second-line induction therapy. Covers monitoring protocols and cycle cancellation criteria for safety.

Lesson 2 • Pharmacology of Ovulation Induction Agents

Reviews mechanisms of clomiphene citrate, letrozole, and gonadotropins in ovulation induction. Provides the pharmacological basis for protocol selection and dosing decisions.

Lesson 3 • IVF Stimulation Protocols

Covers long agonist, antagonist, and flare protocols for controlled ovarian hyperstimulation in IVF. Enables protocol individualization based on ovarian reserve and prior response.

Lesson 4 • Controlled Ovarian Stimulation for IUI

Describes mild stimulation protocols paired with intrauterine insemination for subfertile couples. Balances efficacy with multiple pregnancy risk through careful monitoring.

Lesson 1 • ART Outcome Metrics and Quality Indicators

Defines key ART performance metrics including live birth rate, cumulative success, and laboratory KPIs. Enables critical evaluation of clinic data and benchmarking against published standards.

Lesson 2 • Embryo Transfer Strategies

Compares fresh vs. frozen embryo transfer, single vs. multiple transfer, and endometrial preparation. Guides decisions that balance success rates with multiple pregnancy risk.

Lesson 3 • Donor Gametes and Surrogacy

Addresses clinical, ethical, and procedural aspects of oocyte donation, sperm donation, and gestational surrogacy. Prepares students to counsel patients on third-party reproduction options.

Lesson 4 • Preimplantation Genetic Testing

Explains PGT-A, PGT-M, and PGT-SR indications, biopsy techniques, and result interpretation. Enables informed counseling on genetic testing within ART cycles.

Lesson 1 • Recurrent Pregnancy Loss

Evaluates genetic, anatomical, thrombophilic, and immunological causes of recurrent miscarriage. Applies evidence-based investigation and treatment protocols to improve live birth outcomes.

Lesson 2 • Thyroid and Adrenal Disorders in Reproduction

Examines how thyroid dysfunction and adrenal disorders disrupt reproductive hormonal axes. Applies screening and treatment strategies to optimize fertility and pregnancy outcomes.

Lesson 3 • Fertility Preservation Strategies

Covers oocyte, embryo, and ovarian tissue cryopreservation for oncologic and elective indications. Prepares students to counsel patients on timing, efficacy, and safety of preservation options.

Lesson 4 • Premature Ovarian Insufficiency

Covers POI etiology, hormonal profile, and long-term health consequences including bone and cardiovascular risk. Guides hormone therapy and fertility preservation counseling.